A Review of the Impacts of Sepsis Protocol on Adults Suffering From Sepsis


Sepsis, commonly referred to as blood poisoning, is a debilitating, common, and deadly disease. Sepsis is a Greek word for putrefaction, decayed, and rotten flesh. From a clinical perspective, the term sepsis is used to refer to the system inflammatory response due to microbial infection associated with organ dysfunction. According to the World Sepsis Day (2015), sepsis has a higher probability to cause death compared to cancer and heart attack. The most susceptible and vulnerable populous include older adults and young children with issues of immunology. It is the key contributor to the increased mortality rate of the older population in the U.S. 

PICOT Question

The project will be guided by this PICOT Question: In adult patients with septic shock requiring vasopressors (P), will a target mean arterial pressure (MAP) of 65 mmHg (I) vs. higher MAP (C) improve mortality (O) within the first 24-48 hours of diagnosis(T)? 

Don't use plagiarized sources. Get Your Custom Essay on
A Review of the Impacts of Sepsis Protocol on Adults Suffering From Sepsis
Just from $13/Page
Order Essay

Evidence-Based Solution

Several literature studies have been conducted as an attempt to understand sepsis, as well as septic shock. Angus et al. (2015) conducted a systematic review of sepsis to determine the effect of early-directed therapy on mortality rate in comparison to resuscitating patients suffering from septic shock (Asfar et al., 2014). According to this study, the early goal-directed therapy does not have any form of superiority to care for emergency department patients suffering from septic shock. Research holds that implementing protocols is insufficient (Banerjee et al., 2015). There is a need to take into consideration other open-minded approaches. Such sepsis interventions should have the capacity to cause long-term effects on survivors and restore their functionality level (Zhou, Mao, Zeng, Kang, Liu, Pan, & Hou, 2015)

Nursing Intervention

It is the responsibility of nurses to ensure awareness in regard to sepsis. A lack of awareness has made it difficult to diagnose sepsis at its lowest level, during which any aggressive treatment would solve the issue. Early interventions can improve the outcome by influencing the inflammatory response (Harrison, Gajic, Pickering, & Herasevich, 2016). In addition, nurses are supposed to ensure consistency during the implementation of the system to ensure improved recommendations. Hence, nurses and health providers ought to use EMR, assessments, and clinical judgments to identify a patient’s clinical laboratory values and vital signs with the aim of identifying a dysfunctional organ (Long, Capan, Mascioli, Weldon, Arnold, & Miller, 2018). 

Patient Care

Sepsis shock and sepsis have become a serious health condition in the U.S. It is usually advisable to consider administering early and aggressive sepsis treatment for the purpose of improving the survivability of the patient. In most cases, the patient is treated with vasopressors, antibiotic administration, and intravenous fluids. Immediately after the patient is taken to the ICU, the following assessment must be carried out; blood culture, administered 30ml/kg crystalloid, lactate level measured and administered antibiotics. In patients, they are supposed to utilize the quick sequential organ failure assessment (Qsofa) to determine the presence of sepsis-related organ dysfunction, as well as the level of risk due to clinical decline (Singer et al., 2016).

Healthcare Agency

The inherent challenges in the healthcare environment such as insufficient staffing, inadequate facilities, and funding gaps prompted the government of the United States to interfere. The Agency for Healthcare Research and Quality (AHRQ) is, therefore, responsible for issues related to the provision of high-quality healthcare through research. The agency is responsible for establishing and running health-related facilities such as intensive care units where health conditions such as sepsis are addressed.

Nursing Practice

Nurses and advanced practice nurses are usually authorized, educated, and competent enough to offer professional help in the ICU and any other healthcare related environment. Nursing practice is fundamental in improving the relationship between a patient with septic health problem and nurses. It guides that such a relationship should be founded on trust, communication, kindness, and understanding. Nursing practice is, therefore, essential towards ascertaining that the implementation of a Sepsis protocol in the ICU is efficient and meets threshold requirements.


Angus, D. C., Barnato, A. E., Bell, D., Bellomo, R., Chong, C. R., Coats, T. J., … & Howe, B. (2015). A systematic review and meta-analysis of early goal-directed therapy for septic shock: the ARISE, ProCESS and ProMISe Investigators. Intensive care medicine41(9), 1549-1560.

Asfar, P., Meziani, F., Hamel, J. F., Grelon, F., Megarbane, B., Anguel, N., … & Legay, F. (2014). High versus low blood-pressure target in patients with septic shock. New England Journal of Medicine, 370(17), 1583-1593. doi/full/10.1056/NEJMoa1312173

Banerjee, R., Teng, C. B., Cunningham, S. A., Ihde, S. M., Steckelberg, J. M., Moriarty, J. P., … & Patel, R. (2015). Randomized trial of rapid multiplex polymerase chain reaction-based blood culture identification and susceptibility testing. Clinical Infectious Diseases61(7), 1071-1080.

Harrison, A. M., Gajic, O., Pickering, B. W., & Herasevich, V. (2016). Development and implementation of sepsis alert systems. Clinics in chest medicine37(2), 219-229.

Singer, M., Deutschman, C. S., Seymour, C., Shankar-Hari, M., Annane, D., Bauer, M., Bellomo, R., … Angus, D. C. (2016). The third international consensus definitions for sepsis and septic shock (sepsis-3). Jama – Journal of the American Medical Association, 315(8), 801-810. 

Zhou, F., Mao, Z., Zeng, X., Kang, H., Liu, H., Pan, L., & Hou, P. C. (2015). Vasopressors in septic shock: a systematic review and network meta-analysis. Therapeutics and clinical risk management, 11, 1047.

Place your order
(550 words)

Approximate price: $22

Calculate the price of your order

550 words
We'll send you the first draft for approval by September 11, 2018 at 10:52 AM
Total price:
The price is based on these factors:
Academic level
Number of pages
Basic features
  • Free title page and bibliography
  • Unlimited revisions
  • Plagiarism-free guarantee
  • Money-back guarantee
  • 24/7 support
On-demand options
  • Writer’s samples
  • Part-by-part delivery
  • Overnight delivery
  • Copies of used sources
  • Expert Proofreading
Paper format
  • 275 words per page
  • 12 pt Arial/Times New Roman
  • Double line spacing
  • Any citation style (APA, MLA, Chicago/Turabian, Harvard)

Our guarantees

Delivering a high-quality product at a reasonable price is not enough anymore.
That’s why we have developed 5 beneficial guarantees that will make your experience with our service enjoyable, easy, and safe.

Money-back guarantee

You have to be 100% sure of the quality of your product to give a money-back guarantee. This describes us perfectly. Make sure that this guarantee is totally transparent.

Read more

Zero-plagiarism guarantee

Each paper is composed from scratch, according to your instructions. It is then checked by our plagiarism-detection software. There is no gap where plagiarism could squeeze in.

Read more

Free-revision policy

Thanks to our free revisions, there is no way for you to be unsatisfied. We will work on your paper until you are completely happy with the result.

Read more

Confidentiality Guarantee

Your email is safe, as we store it according to international data protection rules. Your bank details are secure, as we use only reliable payment systems.

Read more

Fair-cooperation guarantee

By sending us your money, you buy the service we provide. Check out our terms and conditions if you prefer business talks to be laid out in official language.

Read more

24/7 Support

Our specialists are always online to help you! We are available 24/7 via live chat, WhatsApp, and phone to answer questions, correct mistakes, or just address your academic fears.

See our T&Cs
Live Chat+1(978) 822-0999EmailWhatsApp

Order your essay today and save 30% with the discount code ESSAYHELP